During industrialization stage when the industry plays the leading role in the development of regional economy, the industrial spatial structure and its evolution not only reflects the regional industrial economic activities and physical elements of the spatial distribution and combination relations, but also determines the main patterns of the regional economic space and the basic direction of its future changes. Therefore, scholars have shown widespread concern to the research into the industrial space structure and its evolution. Deeply involved in globalization, the industrialization in Pearl River Delta is quite different from that in the traditional west developed countries. This difference causes much difficulty in understanding the evolution of industry and spatial landscape. In fact, the dispersive embedded community is the mode of industrial space structure of Pearl River Delta which includes the fundamental elements of village and town, the principal impetus of external capital and labor and the basic factor of industries. Since Pearl River Delta has entered a new stage of industrialization when the heavy industry will play a more important role in promoting the economic development, a great change should be made to the industrial spatial structure in Pearl River Delta. Based on the analysis of the features of heavy industry and the actual industrial spatial structure in Pearl River Delta, the authors studied the evolution of industrial spatial structure caused by the development of heavy industry. It is found that the main effects on spatial structure include the higher degree of centralization of industrial space and forming of new concentrative elements, the prominent core industrial function of big cities and the obvious disparities of industrial development, the emergence of new special industrial zones and industrial node cities, as well as the shifting of industrial space to the coastal regions. At last, the authors put forward some suggestions on how to promote the region's economics and spatial development in harmony.